Volume: 19 Issue-01 (January-June) 2024

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ANTICANCER ACTIVITY (IN VITRO) AND MOLECULAR DOCKING STUDIES OF CAPSAICIN AND MYRISTICIN

ABSTRACT

Cancer is a disease which causes body’s cells grow abnormally and spread to other parts of the body. Cancer treatments are like surgery, chemotherapy, immunotherapy, hormone therapy, radiation therapy and stem cell transplant. Chemotherapy has side effects while doing cancer treatment. Natural treatment, such as the use of plant-derived products in cancer treatment, may reduce adverse side effects. The plant extract samples capsaicin and myristicin chosen are of biological interest with anti-cancerous properties. They are the active compounds of Capsicum and Nutmeg that were extracted using the Soxhlet technique. The ADMET and drug likeness properties of the designated compounds are conferred. Cyclin-dependent kinases (CDKs) are enzymes that have the primary purpose of blocking cellular activity and preventing cell proliferation. CDK2 complexes have significant medicinal targets for the drug design. Molecular docking analysis were considered to examine the inhibitory activities (CDK2 -Inhibitor) of the header composites, to investigate the anticancer efficacy against human colon cancer cell lines using in vitro (MTT assay). The outcome of this analysis suggest that the title compounds might be used as anticancer lead chemicals.

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